To set up your Trezor hardware wallet, visit trezor.io/start. This site provides comprehensive, step-by-step instructions tailored to your specific Trezor model, such as the Trezor One or Trezor Model T. You'll need to download Trezor Suite, connect your device to your computer, and follow the setup wizard to configure your PIN and backup your recovery seed phrase with Trezor.io/start. This process ensures your cryptocurrency is securely managed and protected from the start.